One day glue made of nanoparticles may largely replace sutures and staples in surgery. Imagine being in the hospital with appendicitis. Surgeons remove the appendix through a 3 – 4 inch incision that is usually closed with sutures or staples. However, nanoparticle glues may one day replace these mechanical fasteners as a less invasive and faster method to seal incisions. Minimally invasive closure methods are particularly useful for surgeries with small opening or on delicate tissues, for example eye surgeries. In the past, some research has focused on glues and patches. With nanoparticle glues, the challenge is delivering the compound without clogging the applicator. Using a two-part adhesive avoids this issue by mixing the components at the site of delivery so that they do not adhere to the needle. Researchers have had success with this application method and hope to move into clinical testing.